What exactly is CBDV? Is it more effective than CBD?

 Cannabidivarian (CBDV) is a non-psychotropic homolog of cannabidiol, one of the most important cannabinoids (CBD). CBDV's chemical structure is so similar to CBD's that it can be difficult to distinguish between the two in lab testing.

Both compounds contain the same chemical formula and seven double bond isomers, but their atoms are arranged differently in three dimensions.

The amounts of CBD and CBDV Isolate in the cannabis plant are the most significant distinction between them. Trace levels of CBDV can be found in high-quality full spectrum and broad spectrum extracts, which contribute to the entourage effect.

CBD is one of the most prevalent chemicals in cannabis, whereas CBDV Isolate is found in trace amounts. Because most research on the potential medical benefits focuses on CBD and THC (tetrahydrocannabinol), there aren't as many high CBDV Isolate strains or CBDV-specific products available as there are for many other minor cannabinoids that are quickly gaining popularity (CBN, CBG, and CBC)—but that doesn't mean CBDV Isolate doesn't deserve any attention.

GW Pharmaceuticals, in particular, has supported a significant amount of CBDV Isolate research. According to the findings of these investigations, CBDV Isolate, like CBD, has very comparable potential therapeutic effects as an anticonvulsant, mood regulator, and anti-nausea agent, as well as some neuroprotective qualities.

We'll examine at what the findings means for CBD Vs future and how individuals are using it outside of medications.

TL;DR:

• CBDV Isolate is a minor cannabinoid and a homolog of CBD; they have the same chemical formula but have slightly different atom arrangements. [1]

• CBD and CBDV have very comparable functions in the body, aiding in mood support, healthy cellular function, appropriate inflammation, and nausea control.

• GW Pharmaceuticals is best known for Epiliodex, an anti-epileptic CBD medication. The firm has supported the majority of the CBDV research for its possible application as another prescription drug.

• CBDV has shown substantial promise in alleviating symptoms associated with autism spectrum disorder (ASD) and is now in Phase III clinical trials.

Cannabidivarin Investigation

Because the majority of cannabis research has concentrated on CBD and THC, evidence regarding CBDV Isolate potential medicinal benefits is sparse.

The Food and Drug Administration has currently approved Epidiolex as the sole cannabinoid-based medicine. It is a highly concentrated oral CBD product that is used to treat severe epilepsy.

GW Pharmaceuticals, the pharmaceutical company that manufactured Epidiolex, has also been at the forefront of supporting research on CBDV Isolate and its potential medicinal benefits for over a decade.

CBDV or any other minor cannabinoid has not yet been authorized by the FDA as a therapy or cure for any illness. This is crucial to emphasize because as more CBD brands venture into the world of minor cannabinoids, the marketing language surrounding their benefits becomes confusing. The benefits of CBDV and other substances are often exaggerated in the absence of adequate studies to back them up.

We want to emphasize that the medical cannabinoid area is still very new, although research appears promising. If you wish to incorporate CBDV or another cannabinoid into your health regimen, consult your doctor first, especially if you have an underlying health issue or are taking medication.

Let's have a look at some of the latest CBDV research and its possible therapeutic applications.

1. Autism Spectrum Disorder and CBDV (ASD)

CBDV Isolate is now being studied as a potential therapy for symptoms associated with autism spectrum disorder (ASD).

ASD is a neurodevelopmental disorder with no recognized cure for its primary symptoms. Limited interests, difficulty in social relationships and communication, and repetitive thought patterns and behavior are common symptoms.

This illness is most commonly identified in children under the age of three. According to the medical profession, hereditary factors may increase the likelihood of children acquiring autism spectrum disorder, and some drugs taken by pregnant women may also enhance the risk.

While research is still in its early stages,CBDV Isolate appears to have the ability to help with recurrent behavioral and communication issues. CBDV Isolate was observed to alleviate acute anxiety in individuals by boosting GABA levels in the brain and stimulating the neurotransmitter glutamate in one study [2].

CBD has been proven to have similar effects on the brain as THC. However, prefrontal GABA systems in ASD participants behaved differently than in 'neurotypical' participants, prompting researchers to further examine CBDV Isolate impact on ASD. The same CBDV Isolate study on autistic spectrum disease is now in Phase III clinical trials.

2. CBDV and Severe Epilepsy

Intractable epilepsy, often known as drug-resistant epileptic seizures, is a disease in which seizures are difficult to control with medication. Before releasing Epidoliex for seizures, GW Pharmaceuticals funded preclinical trials to investigate CBDV's potential as an anticonvulsant. According to preliminary research, CBDV Isolate rivaled the benefits of CBD as an anticonvulsant.

CBD and CBDV Isolate are thought to have anti-epileptic properties due to their desensitization of the TRPV1 receptor, also known as the vanilloid receptor. This receptor has been linked to the start and progression of several kinds of epilepsy [1].

CBDV was found to be effective in reducing chemically induced seizures [3]. However, the following stage of these clinical trials was a failure. Since then, GM Pharmaceuticals has focused on CBDV Isolate potential for ASD rather than seizure treatment.

3. CBDV Symptoms Of Nausea

While it is generally annoying and uncomfortable, nausea is one of our body's highly evolved defense mechanisms to assist us get rid of potentially hazardous items we have consumed.

This system is frequently hijacked by other lifestyle factors like as stress or adverse effects from popular medications, which can, in severe situations, interfere with our normal day-to-day functioning.

This study looked at the effects of CBDV Isolate and THCV (delta-9 tetrahydrocannabivarin) on nausea in rats and discovered that they had the opposite effect [4].

4. Duchenne Muscular Dystrophy and CBDV (DMD)

Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle degeneration caused by a lack of the dystrophin protein, which maintains muscle cell integrity, resulting in inflammation and irreversible skeletal muscle degeneration.

Although there is no known treatment for this ailment, steroidal medication and physical therapy can help reduce symptoms.

The Italian National Research Council researched non-euphoric cannabis plant components, specifically CBD, CBDV Isolate, and THCV, to reduce inflammation and support muscle performance.

Researchers discovered that CBD and CBDV both enhanced myotube development (muscle fiber formation) and reduced inflammation in this study [5].

5. Rett Syndrome and CBDV (RTT)

Rett Syndrome (RTT) is a rare neurological condition that is virtually exclusively diagnosed in females. It is caused by a rare gene mutation (MECP2 gene), which results in severe impairments in muscular coordination and speech.

RTT is classified as an autism spectrum condition in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) because patients with Rett syndrome exhibit many autistic symptoms [6].

Because there is no cure for Rett syndrome, current treatments focus on reducing anxiety symptoms and social difficulties in order to improve the quality of life of persons living with RTT.

Researchers discovered that CBDV Isolate delivered to mice improved sociability and partially recovered motor coordination in preclinical experiments [7].