What exactly is CBDA? Everything a Patient Should Know

 

What exactly is CBDA?

CBDA Bulk is a non-psychoactive, acidic cannabinoid that was recently discovered. CBDA is an abbreviation for cannabidiolic acid. CBDA is the acidic form of the well-known cannabinoid CBD (cannabidiol).

Although CBDA Bulk, or cannabidiolic acid, is inactive in its acidic form, this does not mean it does not provide therapeutic benefits. CBDA was discovered in 1955. However, it wasn't until the 1980s that scientists became interested in this molecule. At the time, cannabis laws were extremely harsh and restrictive. As a result, little CBDA Bulk research was conducted until 2018, when the United States and the rest of the world began to accept cannabis as a plant with therapeutic potential.

Decarboxylation

Even before we get into how CBDA Bulk is made, it's worth noting that CBDA is only one "decarboxylation away" from CBD. Decarboxylation is a term that is thrown around a lot in the cannabis industry. This is understandable given that this is the process by which cannabinoids are activated. For example, without decarboxylation, it is impossible to experience the psychoactive effects associated with cannabis consumption.

Carboxylation is a chemical process that removes a carboxyl group from a molecule while also removing a carbon group from the chain. Carboxylation is the process by which a carbon atom is added to the carbon chain in reverse.

As a result, when CBDA is decarboxylated, it loses one carboxyl group and becomes CBD. It also loses its acidic nature and becomes activated during the process. This changes some of its chemical properties and the way it interacts with the human body. This explains why CBD and CBDA have different interactions with the human body; CBDa vs CBD.

Despite the fact that CBDA research is still in its early stages, it is clear that CBDA has significant therapeutic potential. CBDA's anti-nausea properties are one of its most notable therapeutic effects.

CBDA has been shown in studies to alleviate chemotherapy-induced nausea and vomiting. In fact, the study discovered that CBDA Bulk has 1000 times the anti-nausea effects of CBD.

Science surprised us yet again at the start of this year by revealing that acidic cannabinoids, such as CBDA, can reduce sickness from COVID-19 infection. The researchers discovered that some cannabinoids can prevent the COVID-19 virus from entering the human cell in this study. While this cannot prevent infection, it can reduce the severity of the symptoms and may even prevent severe disease. More research in this area will help to clarify the picture.

How Is CBDA Produced?

CBDA Bulk, like CBD, is derived from the "mother of all cannabinoids," cannabigerolic acid (CBGA). The majority of cannabinoids exist in raw cannabis as CBGA.

CBGA is synthesized via an enzymatic reaction involving olivetolic acid and geranyl diphosphate.

CBGA is a precursor molecule for three commonly used acidic cannabinoids:

• THCA (tetrahydrocannabinolic acid) (THCA)

• Cannabidiol (CBD) (CBCA)

• Cannabidiolic acid (CBD) (CBDA)

CBGA is converted to CBDA via an enzymatic reaction catalyzed by CBDA synthase. That is how CBDA is produced.

CBDA is present in trace amounts in cannabis and hemp. This is due to the ease with which CBDA Bulk decarboxylates to form its active form, CBD. Cannabis strains with high levels of CBD, such as Harlequin and ACDC, are likely to have higher levels of CBDA.

With that foundation in place, we can now compare and contrast CBD and CBDA.

CBDA versus CBD

As previously stated, CBDA is the acidic precursor to CBD. CBD cannot exist without CBGA. This reaction requires heat to be catalyzed.

Heat + CBDA = CBD

CBDA and CBD have structurally similar structures, with the exception of one carboxyl group missing in CBD's structure. This is the carboxyl group that is lost during decarboxylation of CBDA. Before we get into the differences (CBDA vs CBD) between CBD and CBDA, let's take a look at some of their similarities.

CBD and CBDA Bulk Share Similarities

Both are cannabinoids found in hemp and cannabis plants.

They are both non-psychoactive.

When Consumed, both have a large margin of safety.

Apart from the extra carboxyl group in CBDA, they have a similar molecular structure.

Both have anti-inflammatory, nausea and vomiting, psychotic, and anxiety properties.

CBDA and CBD are both legal as long as they are derived from hemp.

However, it appears that the two molecules (CBDA vs CBD) have more similarities than differences. The following is a list of the key distinctions between CBD and CBDA.

Differences The distinction between CBD and CBDA

CBDA is acidic, but CBD is not.

The presence of the carboxyl group indicates the acidic form at the molecular level. This has an impact on how CBDA Bulk interacts with the human body. It was once thought that acidic cannabinoids were physiologically inert in the body. This means that when these compounds are consumed, they cannot produce a therapeutic effect. Despite the fact that acidic cannabinoids are not psychoactive, science has demonstrated that they have significant therapeutic potential.

CBD is stable, but CBDA is not.

CBDA is mostly found in newly matured cannabis plants. As the cannabis plant ages, acidic cannabinoids like CBDA Bulk are rapidly converted into their active forms, aka CBD. When CBDA is heated, it decarboxylates and converts to CBD, making it an unstable molecule in contrast to CBD, which can be cooked.

CBD, unlike CBDA, can be consumed in a variety of ways.

This is related to the previous point. CBDA can only be consumed as raw cannabis because it becomes unstable at higher temperatures. CBD, on the other hand, can be smoked, vaped, or infused into foods.

CBDA inhibits COX-2 enzymes, and CBD works through a variety of mechanisms.

Cannabinoids' interactions with the human body are not fully understood. CBD has a low affinity for both CB1 and CB2 receptors. It has an antagonist (contrary) effect on the CB1 receptor and an agonist (helpful) effect on the CB2 receptor. CBD also influenced the serotonin system via serotonin receptors.

CBDA appears to have therapeutic effects by inhibiting COX-2 enzymes, according to preliminary research. In this way, it interacts with the endocannabinoid system indirectly. CBDA also regulates the amount of serotonin in the blood.

CBDA has more potent anti-nausea properties.

One of the most upsetting side effects of cancer chemotherapy is severe nausea. Serotonin levels in the blood are linked to nausea. CBD and CBDA are both involved in the regulation of serotonin, and as a result, they both have anti-nausea properties. However, one study found that CBD has 1000 times the anti-nausea and vomiting effects of chemotherapy.

CBD has received more research than CBDA.

Given that CBD is the poster child for cannabis, this should be a no-brainer. CBD's therapeutic potential as a non-psychoactive cannabinoid has piqued the interest of scientists. CBD research has recently gained popularity. Given the powerful therapeutic effects that have been observed, we anticipate that more researchers will focus on CBDA.

CBD products are more widely available.

CBD products are widely available on the internet. Indeed, some sources claim that the CBD market is already saturated. CBDA, on the other hand, is extremely difficult to come by.

Will CBDA get me high?

All acidic cannabinoids, including cannabidiolic acid, are non-psychoactive. CBDA does not bind to the CB1 receptors, which are responsible for the euphoria associated with cannabis. As a result, CBDA is extremely safe to consume, even by children.

CBDA's Advantages

Previously, it was thought that CBDA was pharmacologically inactive in the human body. This meant that cannabidiolic acid had no significant therapeutic effects. As a result, researchers focused on CBDA and other acidic forms for a long time. However, scientists conducted in vivo CBDA studies over a decade ago. CBDA has been discovered to be bioactive and has therapeutic potential. As a result, several studies have been conducted to investigate how CBDA interacts with the human body.

CBDA does not appear to bind to cannabinoid receptors directly (CB1 &CB2). Instead, it inhibits a class of enzymes known as COX-2 enzymes. CBDA reduces inflammation by inhibiting these enzymes, which are expressed in inflammatory cells.

CBDA also has a high affinity for serotonin receptors. It has 100 times the affinity for these receptors as CBD. This receptor family is involved in nausea and vomiting, mood regulation, and intestinal motility.

CBDA and Pain

CBDA is effective in relieving inflammatory pain caused by inflammatory conditions such as arthritis. CBDA is a COX-2 inhibitor that is highly selective. According to some studies, CBDA's inhibitory effects on COX-2 enzymes are 1000 times stronger than that of traditional anti-inflammatory drugs like ibuprofen.

Cannabidiolic acid, unlike NSAIDs, is selective for COX-2 receptors. NSAIDS also inhibit COX-1 enzymes, which are involved in intestinal motility. When this happens, the motility of the intestines is disrupted. As a result, the integrity of the intestinal lining is compromised, leading to ulcers. For this reason, long-term use of nonsteroidal anti-inflammatory drugs is discouraged. CBDA, on the other hand, can be used safely for very long periods of time.

CBD vs. CBDA for Nausea

CBD and CBDA Isolate For Sale both have strong anti-nausea properties. Preliminary research indicates that they can be used to treat chemotherapy-induced nausea and vomiting. However, it appears that CBDA has more potent anti-nausea properties. This is something that researchers are interested in because it shows a lot of promise in the treatment of severe nausea.

Guelph University researchers conducted a study that compared the effects of both cannabinoids on different types of nausea. The findings revealed that CBDA has potent anti-nausea properties when exposed to motion or toxins.

Furthermore, the study found that CBDA was very effective in relieving anticipatory nausea. This type of nausea is common during chemotherapy. This makes CBDA a potential treatment for chemotherapy-induced nausea and vomiting.

Another study looked into the anti-nausea effects of cannabidiolic acid and ondansetron when used together. Ondansetron is a common anti-nausea medication. The study discovered that CBDA enhances the anti-nausea effects of ondansetron, even at very low doses.

CBDA's Anti-Tumor Effects

Cannabinoids' anticancer properties are causing quite a stir in medical circles. While the majority of the health benefits for cancer are preclinical, it lays the groundwork for future research. Cannabidiolic acid (CBDA) has also shown promise as an antitumor agent against breast cancer cells. CBDA was found to downregulate COX-2 enzymes in a type of breast cancer with a high concentration of COX-2 enzymes in one preclinical study.

CBD vs. CBDA for Anxiety

CBD's anti-anxiety properties are well established. CBDA's anti-nausea effects are new and promising. A 2013 Canadian study discovered that CBDA had powerful anti-anxiety effects. CBDA was 1000 times more potent than CBD in this regard.

CBDA interacts with the serotonin system, which regulates anxiety. As a result, CBDA is an effective agent for treating chemotherapy-related nausea and anxiety.

CBDA Products

CBDA Isolate For Sale is mostly found in raw cannabis, as flowers and leaves from the cannabis plant. When CBDA is heated, it decarboxylates and converts to CBD. As a result, the best way to consume CBDA is in its raw form. Raw CBDA Isolate For Sale can be consumed in the following ways:

• Hemp juices

• Smoothies

• Salads

• Garnishes

• Lightly steamed leaves

Raw CBDA-containing cannabis flowers can be stored in the refrigerator for later use. To keep the flowers crisp, wrap them in a wet kitchen cloth.

CBDA Products Available Online

If you're patient enough to find a reputable dealer, you can also find some high-quality CBDA Isolate For Sale products online. The best CBDA oils must be third-party tested to ensure their potency and purity.

CBDA side effects

CBDA Isolate For Sale may cause mild side effects in some users. This can include headaches, GI disturbances, and fatigue. If you experience any side effects, stop taking the medication and consult your doctor.

Is CBDA Better Than CBD?

CBDA Isolate For Sale and CBD are similar in many ways while also having significant differences. CBD can be consumed in more ways than CBDA. Furthermore, CBD is more stable in its natural state. Aside from that, both compounds have significant therapeutic potential. Preliminary evidence suggests that CBDA may be a more potent compound pharmacologically.