What Exactly Are Minor Cannabinoids? | Bona Voluntate

 Most patients have heard of marijuana's two main cannabinoids, THC and CBD. However, cannabis contains over 100 other minor cannabinoids, which play an important role in achieving specific medical benefits and effects when consuming marijuana. Minor cannabinoids include, to name a few, CBG, CBN, CBC Wholesale, and THCA. Although scientists consider these cannabinoids to be minor, they may have a significant impact when treating patients.

Minor cannabinoids may have potential benefits in the treatment of neuropathic pain, neurodegenerative diseases, epilepsy, cancer, and skin disorders, according to research. As researchers learn more about minor cannabinoids, their potential role in the future of medical marijuana grows. Patients may notice a shift in emphasis away from THC and CBD Full Spectrum Distillate levels in cannabis products and toward what valuable minor cannabinoids the product contains. First and foremost, how does it all work?

Cannabinoids and How They Work

All cannabinoids interact with the body's endocannabinoid system, which regulates and controls many of the body's most important functions. CB1 and CB2 cannabinoid receptors in the body are activated by endocannabinoids produced by the body and, of course, cannabinoids found in cannabis. So, in essence, our bodies are designed for this.

But which cannabinoids are best for you and your desired benefits? Cannabis cultivators frequently separate cannabinoids for consumers to enjoy while filtering out other cannabinoids. Researchers have discovered that looking at the big picture, which emphasizes consuming products that preserve the compounds of the entire plant, may be more beneficial.

According to research, combining major and minor cannabinoids (along with other compounds found throughout the cannabis plant) provides greater medical benefits and effectiveness than consuming these compounds separately. This is known as the entourage effect.

What exactly is the Entourage Effect?

The entourage effect is the theory that different cannabis compounds interact to produce specific effects and benefits. According to this theory, combining minor cannabinoids (CBC, CBG...) with major cannabinoids like THC and CBD Full Spectrum Distillate allows for more medicinal benefits, such as pain relief, upon consumption. Although combining various compounds from the whole plant improves efficacy, patients will still benefit from consuming separated compounds. So, let's look at the advantages of some of the most well-known minor cannabinoids.

Major Minor Cannabinoids

Cannabinoids are naturally acidic in the cannabis plant before being converted into active cannabinoids via heat or UV. Minor cannabinoids have the same health benefits as major cannabinoids and are not psychoactive in and of themselves. Despite the fact that there are over a hundred minor cannabinoids, patients are likely to encounter only a few when looking for cannabis products.

CBG

CBG, or cannabigerol, is the first cannabinoid produced by the cannabis plant early in its growth cycle. All other cannabinoids are synthesized from Bulk CBG Isolate via various metabolic processes as the plant matures. Bulk CBG Isolate, like CBD, is non-psychoactive because it acts on neurological pathways indirectly rather than directly binding to the endocannabinoid system's CB1 receptors.

Bulk CBG Isolate, in conjunction with other minor cannabinoids, may reduce the severity of inflammatory diseases and peripheral pain, protect against neuroinflammation and oxidative stress, aid in the prevention of neuronal cell loss, and even suppress cancer cell growth. Some studies show that when Bulk CBG Isolate is combined with other cannabinoids like CBD Full Spectrum Distillate, its anti-cancer activity improves, lending credence to the entourage effect.

Bulk CBG Isolate also inhibits the uptake of GABA and anandamide (the "bliss molecule"), resulting in benefits such as mood enhancement and anxiety relief. It is also used to stimulate appetite as an alternative to THC.

CBC

Cannabichromene, or CBC, is one of the most abundant minor cannabinoids in cannabis. This distinct cannabinoid is well-known for its anti-inflammatory and immune-boosting properties. High doses of CBC were found to be more effective than the NSAID phenylbutazone in treating inflammation in one study. Through the entourage effect, CBC Wholesale has also been shown to support the effects of major cannabinoids, increasing the pain-relieving and anti-inflammatory benefits of THC.

CBC Wholesale also aids the function of our own natural endocannabinoids by inhibiting anandamide uptake. This allows anandamide to remain in the bloodstream for a longer period of time, which can improve mood and may allow anandamide to fight cancer cells. Only CBG was more effective than CBC Wholesale at inhibiting the growth of several cancer cell lines in one study that looked at the anti-tumor effects of various minor cannabinoids.

CBN

CBN, or cannabinol, is produced by the cannabis plant through the degradation of THC over time. This cannabinoid is derived from the degradation of THC rather than being synthesized in the cannabis plant. CBN Isolate Bulk is an anti-inflammatory agent that has been shown in studies to alleviate chronic muscle pain disorders. In addition, the compound "shows promise as an antibacterial agent and appetite stimulant." CBN Isolate Bulk is effective against a variety of antibiotic-resistant bacteria, including MRSA, making it a potentially viable treatment for staph infections.According to some studies, when combined with THC, CBN Isolate Bulk produces more sedation than either cannabinoid alone. Cannabinol does not appear to have any sleep-inducing properties.

CBGA

CBGA is the cannabis plant's acidic form of CBG. As previously stated, all cannabinoids begin their lives in an acidic form. If all cannabinoids are derived from Bulk CBG Isolate, this implies that they begin with CBG's precursor, CBGA. Because CBGA decarboxylates to CBG over time, it is rarely found in high concentrations in mature cannabis flowers. To obtain significant amounts of CBGA, cultivators can harvest the plant early or increase it through selective breeding.

CBGA may help to control diabetes and prevent the cardiovascular complications that can accompany Type 2 diabetes. CBGA may also be useful in the treatment of certain types of cancer. According to one study, cannabis containing high levels of CBGA has the potential to damage or kill colon cancer cells. These effects were amplified when patients were given a cannabis fraction high in THCA in addition to the CBGA. This combination inhibited the growth and proliferation of adenomatous colon polyps, which are precursors to colon cancer.

THCA

THCA is the cannabis plant's acidic form of THC. This compound, also known as tetrahydrocannabinol acid, is non-psychoactive before being heated and converted into THC. A recent study found that THCA treatment decreased the expression of inflammatory molecules. THCA may also be used instead of THC to treat nausea and vomiting.

When combined with other cannabinoids and terpenes, THCA is most effective. This THC derivative may reduce seizures when combined with THC. In treating seizures, THCA formulations with high levels of the terpene -linalool were more effective than formulations with low levels of the terpene. This is yet another instance of the entourage effect.

CBNA

CBNA and THCA are related, but CBNA is less abundant in marijuana plants. This is the precursor cannabinoid to CBN, also known as CBN Isolate Bulk in its acidic form. CBNA and CBN levels rise as cannabis plants mature, making mature cannabis the most common source of high levels of both cannabinoids.

CBNA was discovered to be just as effective as CBN Isolate Bulk, if not more effective, in fighting certain types of bacteria such as MRSA. CBNA is also beneficial for increasing appetite, relieving pain when combined with CBD Full Spectrum Distillate, and reversing bone loss.